As part of its Hirschmann Lecture Series, the Department of Chemistry and Biochemistry hosts guest speaker Paramjit S. Arora, professor of chemistry at New York University. The topic of his presentation will be ‘‘Mimicry of protein surfaces with peptides and peptidomimetics.’’
The seminar will be preceded by a reception at 4:30 p.m., in the David Love Lounge.
Sponsored by the Ralph F. Hirschmann Lectureship Fund.
Development of specific ligands for protein targets that help decode the complexities of protein-protein interaction (PPI) networks is a key goal for the field of chemical biology. Despite the emergence of powerful in silico and experimental high-throughput screening strategies, the discovery of synthetic ligands that selectively modulate protein-protein interactions remains a challenge.
We are developing a systematic approach to develop synthetic inhibitors of PPIs. Proteins often utilize small folded domains for recognition of other biomolecules. The basic hypothesis guiding our research is that by mimicking these domains we can modulate the function of a particular protein with metabolically stable synthetic molecules.
This presentation will discuss computational and synthetic methods to develop protein domain mimics (PDMs) as modulators of intracellular protein-protein interactions.