Oberlin College and Conservatory

Chemistry & Biochemistry Seminar Series: Melanie Rosay '95

Wednesday, April 4, 2018 at 4:45pm

Science Center, A255
119 Woodland Street, Oberlin, OH 44074

The Department of Chemistry and Biochemistry hosts guest speaker Melanie Rosay '95, HyperPolarization Portfolio Manager at Bruker BioSpin, whose topic will be "Dynamic Nuclear Polarization for Sensitivity-Enhanced Solid-State NMR: from Academia to Industry."

The seminar will be preceded by a reception at 4:30 p.m., in the David Love Lounge.

Sponsored by the Luke E. Steiner Lecture Fund.

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Dynamic Nuclear Polarization (DNP) experiments transfer the high Boltzmann polarization of unpaired electron spins to nuclear spins for large gain in sensitivity (hyperpolarization) and dramatic reduction in signal averaging time. This sensitivity gain opens the door to applications in solid-state NMR that may not have been achievable otherwise, and a range of applications have been demonstrated spanning from small molecules to large biological complexes and materials. The polarization transfer is driven by microwave irradiation of the electron spins near their Larmor frequency. For DNP experiments at 1H NMR frequencies in the range of 400-900 MHz, microwave sources operating in the range of 263-593 GHz are required with high output power, spectral purity, and frequency and power stability. However, the dearth of suitable microwaves sources at this high frequency range had traditionally limited DNP to select academic research groups.

In the past decade, methods for the hyperpolarization of nuclear spins have made great strides to move from basic research and development to more widespread NMR applications. In that timeframe, Bruker has developed both instrumentation and methods to assist progress in the field and reach new application areas.   I will present and introduction to hyperpolarization and DNP, highlight seminal contributions from the field, and discuss in more details the developments at Bruker to bring solid-state DNP instrumentation from an academic setting to a successful commercial product.   Interspersed will be some personal anecdotes on a career in industry and the influence of my undergraduate time at Oberlin College.

 

Event Type

Lectures/Symposia/Workshops

Departments

Academic, Chemistry and Biochemistry

Cost

Free and open to the public

Contact Person

Rachel Wysocki

Contact Phone Number

(440) 775-8300

Contact E-mail Address

chemistry@oberlin.edu

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