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VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Chem. & Biochem. Seminar Series: Sara E. S. Martin
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260811T181239Z
UID:tag:localist.com\,2008:EventInstance_41360020559570
DTSTART:20221026T204500Z
DTEND:20221026T214500Z
DESCRIPTION:The Department of Chemistry and Biochemistry hosts guest speake
 r Sara E. S. Martin\, Assistant Professor of Chemistry at The College of W
 ooster. Her topic will be "Tools for Attenuating Activity of Glycosyltrans
 ferases."\n\nThe seminar will be preceded by a light reception at 4:30 p.m
 . in the David Love Lounge.\n\nSponsored by the Luke E. Steiner Lecture Fu
 nd.\n\n--\n\nAbstract:\n\nEnzymes are Nature’s catalysts\, but too much 
 reactivity can lead to disease. Sometimes we need to put on the breaks to 
 understand an enzyme’s function. Our lab is investigating a new way to m
 ake unique heterocycles\, known as 7-substituted quinolinones\, that could
  be good starting points for inhibitors of glycosyltransferase enzymes. Th
 ere are limited ways to construct these heterocycles from simple\, commerc
 ially available starting materials\, and many of the existing methods do n
 ot provide access to products with substitution at the 7-position of the q
 uinolinone ring. Existing syntheses rely heavily on oxidation state manipu
 lations or on prefunctionalized starting materials rather than on building
  up the quinolinone framework from simple and readily accessible starting 
 materials. We are investigating whether 3-substituted anilines can be used
  in an acylation-cyclization sequence to selectively form exclusively 7-su
 bstituted products. Our results indicate that 7-substituted quinolinones a
 re the major products in these reactions\, but yields and selectivities di
 ffer depending on the nature of the aniline substrate. \n\nThe final minut
 es of the talk will focus on the Phone a STEM Professional assignment\, wh
 ich asks students to conduct an informational interview with a STEM profes
 sional and reflect on their experience. I am investigating the effect of t
 he assignment on student career aspirations\, confidence in intended caree
 r path\, and sense of belonging in STEM\, all of which are positively infl
 uenced by participation in this assignment.
GEO:41.294861;-82.222229
LOCATION:Science Center\, A254
SUMMARY:Chem. & Biochem. Seminar Series: Sara E. S. Martin
URL;VALUE=URI:https://calendar.oberlin.edu/event/chem_biochem_seminar_serie
 s_sara_e_s_martin
CATEGORIES:Lectures/Symposia/Workshops
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END:VCALENDAR